SCIENTIFIC PEER REVIEWED INDEPENDENT STUDIES ON ASPARTAME



Posted: 13 August 2011


High Blood Alcohol Levels In Women: The Role Of Decreased Gastric Alcohol Dehydrogenase Activity And First-Pass Metabolism (Mario Frezza, MD; Carlo Di Padova, MD; Gabriele Pozzato, MD; Maddalena Terpin, MD; Enrique Baraona, MD; and Charles S. Lieber, MD) The New England Journal Of Medicine January 11, 1990 Vol. 322, No. 2

Glial Cell Diversification In The Rat Optic Nerve (Martin C. Raff) Science, VOL. 243 17 March 1989

Mutagenic Activity Of Peptides And The Artificial Sweetener Aspartame After Nitrosation (S.E. Shephard, K. Wakabayashi, and M. Nagao) Fd. Chem. Toxic Vol. 31, No. 5, pp 323-329, 1993

Effect of Aspartame In Normal and Diabetic Rats (V.M. Sardesai, J.F. Holliday, G.K. Kumar, and J.C. Dunbar) Biochemical Archives, Vol. 2, pp. 237-243, 1986

Effect Of Hyperglycemia On Gastric Acid Secretion And Gastrin Release Induced By Intravenous Amino Acids (Wai F. Lam, Ad AM Masclee, Eveline SM Muller, and Cornelis BHW Lamer) American Society for Clinical Nutrition 1995; 61:1268-72

Underreporting Research Is Scientific Misconduct (Lain Chalmers, FRCOG) JAMA, March 9. 1990­Vol 263, No. 10

Neurological Deterioration In Young Adults With Phenylketonuria (Author Unknown) The Lancett VOL 336 October 13, 1990

Identification Of A Polymorphism In The Human Neurotensin Receptor Gene (Michael Watson, BS; Paul J. Isackson, PhD; Manisha Makker, Mitsuhiko S. Yamada, MD, PhD; Misa Yamada, B.S.; Bernadette Cusack, BA, MAT; and Elliott Richelson, MD) Mayo Clinic Proceedings Volume 68: 1043-1048 November 1993

The Effect Of L-Dopa Infusions With And Without Phenylalanine Challenges In Parkinsonian Patients: Plasma And Ventricular CSF L-Dopa Levels And Clinical Responses (W.R. Woodward, PhD; C.W. Olanow, MD; R.M. Beckner, BS; R.A. Hauser, MD; L.L. Gauger, BA; J.M. Cedarbaum, MD; and J.G. Nutt, MD) From the Department of Neurology, Biochemistry and Molecular Biology, and Pharmacology, Oregon Health Sciences University, Portland, OR Neurology 43 September 1993

Maternal Mild Hyperphenylalaninaemia: An International Survey Of Offspring Outcome (Harvey L Levy; Susan E Waisbren, Deborah Lobbregt, Elizabeth Allred, Agnes Schuler, Friedrich K Trefz, Susanne M Schweitzer, I B Sardharwalla, J H Walter, B E Barwell, Cheston M Berlin Jr, Alan Leviton) The Lancett Vol 344 December 10, 1994

Anaphylaxis: A review Of 266 Cases (Stephen F. Kemp, MD; Richard F. Lockey, MD; Bruce L. Wolf, MD; Phil Lieberman, MD) ARC INTERN MED/VOL 155. SEP 11, 1995

Aminoacid Polymorphisms Of Insulin Receptor Subtrate-1 In Non-Insulin-Dependent Diabetes Mellitus (Katrine Almind, Christian Bjorbaek, Henrik Vestergaard, Torben Hanson, Soren Echwald, Oluf Pederson) The Lancet 1992: 342: 828-32

HLA-DQB1 Alleles And Absence Of Asp 57 As Susceptibility Factors Of IDDM In Finland (Helena Reijonen, Jorma Ilonen; Mikael Knip; and Hans K. Akerblom) Diabetes, VOL 40, December 1991

Impaired Performance On Odor-Aversion Testing Following Prenatal Aspartame Exposure In The Guinea Pig (Diana L. Dow-Edwards; Louise A. Scribani and Edward P. Riley) Neurotoxicology and Teratology, Vol. 11, pp. 413-416 Pergamon Press plc, 1989

Plasma Levels Of Amino Acids Correlate With Motor Fluctuations In Parkinsonism (Jonahan H. Pincus, MD; Kathryn M. Barry, MSN, RN) Parkinsonism-Pincus & Barry Arch Neurol-Vol 44, Oct 1987

Plasma Amino Acid Concentrations In Normal Adults Ingesting Aspartame And Monosodium L-Glutamate As Part Of A Soup/Beverage Meal (Lewis D. Stegink, L.J. Filer, Jr, and George L. Baker) Metabolism, Vol 36, No 11(November), 1987: pp 1073-1079

Benzoate Derivatives As Intermediates In The Biosynthesis Of Coenzyme Q In The Rat (Robert E. Olson, Ronald Bentley, A.S. Aiyar, G. Hossein Dialameh, Philip H. Gold, Virginia G. Ramsey, and C.M. Springer) The Journal of Biological Chemistry Volume 238 1963 PP PC 3146-3148

Artificial Food Additive Intolerance In Patients With Angio-Oedema And Urticaria (G. Supramaniam and J.O. Warner) The Lancet, October 18, 1986

Suicides Among Persons 15-24 Years Of Age, 1970-1984 (Linda E. Saltzman, PhD; Amy Levenson, MD; Jack C. Smith, MS) Publication, Unknown Vol. 37, No. SS-1 Is An Elevated Concentration Of Acinar Cytosil Free Ionized Calcium The Trigger For Acute Pancreatitis? J.B. Ward, O.H. Peterson, S.A. Jenkins, R Sutton) The Lancett 1995; 346: 1016-19

Fulminant Pancreatitis Associated With Lisinopril Theraphy (John B. Standridge, MD) Southern Medical Journal February 1994 Vol. 87, No. 2

Epilepsy Precipitated By Food Sensitivity: Report Of A Case With Double-Blind Placebo-Controlled Assessment (John W. Crayton, Thomas Stone, and Gerald Stein) Clinical Electroencephalogaphy 1981 Vol. 12, No. 4

Alcohol Withdrawal And Noradrenergic Function Moderator: Markku Linnoila, MD, PhD; Discussants: Ivan Mefford, PhD; David Nutt, MD, PhD; and Bryon Adinoff, MD) Annals of Internal Medicine Vol. 107; No. 6 December 1987

Resurgence of Acute Rheumatic Fever In The Intermountain area of the United States (L. George Veasey, MD; Susan E. Wiedmeier, MD; Garth S. Orsmond, MD; Herbert D. Ruttenberg, MD; Mark M. Boucek, MD; Stephen J. Roth, MD; Vera F. Tait, MD; Joel A. Thompson, MD; Judy A. Daly, PhD; Edward L. Kaplan, MD; and Harry R. Hill, MD) The New England Journal of Medicine Volume 316 February 19, 1987 Number 8

Intestinal Hydrolysis Of Aspartylphenylalanine- The Metabolic Product Of Aspartame (Nelia A. Tobey and William D. Heizer) Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill NC Gastroenterology 1986; 91:931-7

Aspartame-Associated Confusion And Memory Loss A Possible Human Model For Early Alzheimer's Disease (H.J. Roberts, MD) Clinical Study, Year Unknown

Aspartame As A Dietary Trigger Of Headache (Richard B. Lipton, MD; Lawrence C. Newman, MD; Joel S. Cohen, MD; and Seymour Solomon, MD) Headache 29:90-92, 1989

Synthesis, Taste Properties, And Conformational Analysis Of Four Stereoisomeric Cyclopropane Analogs Of Aspartame (Claudio Mapelli, Charles H. Stammer, Stan Lok, Dale F. Mierke, and Murray Goodman) Int. J. Peptide Protein Res. 32, 1988, 484-495

Effect Of Hyperglycemia On Gastric Acid Secretion And Gastrin Release Induced By Intravenous Amino Acids (Wai F. Lam; Ad AM Masclee; Eveline SM Muller; and Cornelis BHW Lamers) The American Society for Clinical Nutrition 1995; 61: 1268-72

Reactions Attributed To Aspartame-Containing Products: 551 Cases (Hyman J. Roberts, MD) Journal of Applied Nutrition, Volume 40, Number 2, 1988

Fatal And Near-Fatal Anaphylactic Reactions To Food In Children And Adolescents (Hugh A. Sampson, M.D.; Louis Mendelson, M.D.; and James P. Rosen, M.D.) The New England Journal of Medicine 1992; 327:380-4

Subverting Randomization In Controlled Trials (Kenneth F. Schulz, PhD, MBA) JAMA, November 8, 1995­Vol 274, No. 18

Plasma Amino Acid Concentrations In Geriatric Control And Hip-Fracture Patients (Calvin L. Long; John W. Geiger; Ernest W. Richards; John M. Akin; and William S. Blakemore) The American Society for Clinical Nutrition 1992; 55: 1135-41

Hypoglycemic Action Of Tryptophan (H.G. McDaniel, M.D.; B.R. Boshell, M.D.; and W.J. Reddy, Sc. D.) From the Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama School of Medicine and the Diabetes Research Laboratory, Veterans Administration Hospital, Birmingham, Alabama 35233 September 1973 Diabetes, Vol. 22. No. 9

Role Of Insulin In Amino Acid Metablism (William W. Lacy, MD) Southern Medical Journal, January 1973-Vol 66, No. 1

Aspartame: Clinical Update (Daniel P. Potenza, MD; and Rif S. El-Mallakh, MD) Connecticut Medicine, July 1989 Volume 53, NO. 7

The Effect of Protein Restriction On The Progression Of Renal Insufficiency (Benno U. Ihle, M.B., B.S.; Gavin J. Becker, M.D.; Judith A. Whitworth, M.D., Ph.D.; Robyn A. Charlwood, B.Sc.{HON}; and Priscilla S. Kincaid-Smith, D. Sc., M.D.) The New England Journal of Medicine Volume 321 December 28. 1989 Number 26

Tourette's Syndrome (Ceasr C. Santons, MD; E. Wayne Massey, MD) Vol 87/NO 2/February 1, 1990/PostGraduate Medicine

L-Cysteine, A Bicarbonate-Sensitive Endogenous Excitotoxin (John W. Olney, Charles Zorumski, Madelon T. Price, Joann Labruyere) Washington University School of Medicine, Department of Psychiatry, St. Louis, MO 63110 Science, Vol. 248 4 MAY 1990

(Kaoru Aida, MD; Masato Tawata, MD, PhD; Hideo Shindo, MD; Toshimasa Onaya, MD, PhD) Diabetes Care, Vol. 13, NO. 5, May 1990

Dementia and motoneurone disease (Author Unknown) The Lancett Vol. 335 May 26, 1990

The Neuropsychiatric Effects Of Aspartame In Normal Volunteers (Katherine A. Lapierre, MD; David J. Greenblatt, MD; Jill E. Goddard, MA; Jerold S. Harmatz; and Richard I. Shader, MD) The Division of Clinical Pharmacology 1990; 30:454-460

Increased Neuropeptide Y Concentrations In Specific Hypothalamic Regions Of Streptozocin-Induced Diabetic Rats (Gareth Williams, Jaswinder S. Gill, Ying C. Lee, Helena M. Cardoso, Benjamin E. Okpere, and Stephen R. Bloom Diabetes 38" 321-27, 1989, Volume 38

Induction Of A Neuronal Proteoglycan By The NMDA Receptor In The Developing Spinal Cord (Robert G. Kalb; and Susan Hockfield) Section of Neuroanatomy, Yale University School of Medicine, New Have, CT 06510 Science, VOL 250 October 12 1990

Hypothesis: Does Breast Cancer Originate In Utero? (Dimitrios Trichopoulos) The Lancett VOL 335 April 21, 1990

The Effect Of L-Dopa Infustions With And Without Phenylalanine Challenges In Parkinsonian Patients (W.R. Woodward, PhD; C.W. Olanow, MD; R.M. Beckner, BS; R.A. Hauser, MD; L.L. Gauger, BA; J.M. Cedarbaum, MD; and J.G. Nutt, MD) Neurology 43 September 1993

Neurological Deterioration In Young Adults With Phenylketonuria (Alan J. Thompson; I. Smith; D. Brenton; B.D. Youl; G. Rylance; D.C. Davidson; B. Kendall; A.J. Lees) The Lancett SEPT 8, 1990 336:602-05

Repeated Ingestion of Aspartame-Sweetened Beverage: Effect On Plasma Amino Acid Concentrations In Normal Adults (Lewis D. Stegink, L.J. Filer, JR, and George L. Baker) The Departments of Pediatrics and Biochemistry, University of Iowa College of Medicine, Iowa City Metabolism, Volume 37, NO 3 (March) 1988: pp. 246-251

Bioavailability Of Phenylalanine And Aspartate From Aspartame (20 mg/kg) In Capsules And Solution (Thomas S. Burns; W. Wayne Stargel; and Aryeh Hurwitz) The Department of Clinical Research Metabolism, Vol 39, No 11(November), 1990: pp 1200-1203

Oral Stimulation With Aspartame Increases Hunger (Michael G. Tordoff; and Annette M. Alleva) Physiology & Behavior, Vol. 47. pp. 555-559. Pergamon Press plc, 1990.

Amino Acid Composition Of Myelin In Multiple Sclerosis (Frederick Wolfgram, PhD; Wallace W. Tourtellotte, MD, PhD) The Department of Neurology, Reed Neurological Research Center, University of California School of Medicine, Los Angeles, and the Neurology Service, Wadsworth Hospital, Los Angeles Veterans Administration Center Neurology/ Volume 22/ October 1972

Serum Estradiol But Not Gonadotropin Levels Decrease Acutely After Insulin-Induced Hypoglycemia In Cycling Women (Robert G. Bing-You; and Daniel I. Spratt) Journal of Clinical Endocrinology and Metabolism Vol. 75, No. 4 1992

Incidence Of Brain Tumors In Rats Fed Aspartame (Hiroyuki Ishii) Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc., Yokohama 244 Japan Toxicology Letters, 7(1981) 433-437

Aspartame Ingestion And Headaches: A Randomized Crossover Trial (S.K. Van Den Eeden, PhD; T.D. Koepsell, MD, MPH; W.T. Longstreth, Jr., MD, MPH; G. Van Belle, PhD; J.R. Daling, PhD; and McKnight, PhD.) The Departments of Epidemiology October 1994; 44:1787-1793 Neurology

Children's Food Intake Following Drinks Sweetened With Sucrose Or Aspartame: Time Course Effects (Leann Lipps Birch, Linda McPhee, and Susan Sullivan) Physiology & Behavior, Vol. 45, pp. 387-395. Pergamon Press plc, 1989

Evidence For An Intracerebral Action Of Phenylalanine In Stimulation Of Prolactin Secretion: Interaction Of Large Neutral Amino Acids (Harold E. Carlson, David B. Hyman, and Miriam G. Blitzer) Journal of Clinical Endocrinology and Metabolism Vol. 70, No. 3 1990

Prolactin Stimulation By Protein Is Mediated By Amino Acids In Humans (Harold E. Carlson) Journal of Clinical Endocrinology and Metabolism Vol. 69, No. 1 1989

Possible Neurologic Effects Of Aspartame, A Widely Used Food Additive (Timothy J. Maher; and Richard J. Wurtman) Environmental Health Perspectives Volume 75, pp. 53-57, 1987

Effects Of Sugar And Aspartame On Aggression And Activity In Children (Markus J.P. Kruesi, MD; Judith L. Rapoport, MD; E. Mark Cummings, PhD; Carol J. berg, MA; Deborah R. Ismond, MA; Martine Flament, MD; Marian Yarrow, PhD; and Carolyn Zahn-Waxler, PhD) American Journal Psychiatry 1987; 144: 1487-1490

Hemoglobin Yoshizuka (G10(108)B Asparagine­Aspartic Acid: A New Variant With A Reduced Oxygen Affinity From A Japanese Family (Takashi Imamura; Shigeru Fujita; Yoshiro Ohta; Motosuke Hanada; and Toshiyuki Yanase) The Journal of Clinical Investigation Volume 48 1969

A Comparison Of Symptoms After The Consumption Of Milk Or Lactose-Hydrolyzed Milk By People With Self-Reported Severe Lactose Intolerance (Fabrizis L. Suarez, M.D.; Dennis A. Savalano, Ph.D.; and Michael D. Levitt, M.D.) The New England Journal of Medicine Volume 333, July 6 1995, Number 1

Adverse Reactions To Aspartame: Double-Blind Challenge In Patients From A Vulnerable Population (Ralph G. Walton, Robert Hudak, and Ruth J. Green-Waite) Society of Biological Psychiatry 1993; 34: 13-17

The Inheritance Of Gilles De La Tourette's Syndrome And Associated Behaviors (David L Pauls, PhD; and James F. Leckman, MD) The Child Study Center Vol. 315 No. 16 October 16, 1986

Hypertension Prevention Trial: Do 24-H Food Records Capture Usual Eating Behavior In A Dietary Change Study? (Jean L. Forster, Robert W. Jeffery, Mark VanNatta, and Phyllis Pirie) The American Journal of Clinical Nutrition 1990; 51: 253-7

Extracellular Hippocampal Glutamate And Spontaneous Seizure In The Conscious Human Brain (Mathew J. During; Dennis D. Spencer) The Lancet Vol. 341 Saturday 26 June 1993 No. 8861

Detection Of Mutations In The Tyrosinase Gene In A Patient With Type IA Oculocutaneous Albinism (Richard A. Spritz, MD; Kathleen M. Strunk, B.S.; Lutz B. Giebel, Ph.D.; and Richard A. King, M.D., Ph. D) The New England Journal of Medicine June 14, 1990 Vol. 322 No. 24

The Return Of Acute Rheumatic Fever In Young Adults (Mark R. Wallace, MD; Paul D. Garst, MD; Thomas J. Papadimos, MD; Edward C. Oldfield III, MD) JAMA, November 10, 1989-Vol 262, No. 18

Mutagenic Activity Of Peptides And The Artificial Sweetener Aspartame After Nitrosation (S.E. Shephard; K. Wakabayashi and M. Nagao) Fd Chem. Toxic. Vol. 31, No 5, pp. 323-329, 1993

"hree-Dimensional Structures Of The Ligand-Binding Domain Of The Bacterial Aspartate Receptor With And Without A Ligand (Michael V. Milburn; Gilbert G. Prive; Daniel L. Milligan; William G. Scott; Joanne Yeh, Jarmila Jancarik; Daniel E. Koshland, JR; Sung-Hou Kim) Science Vol. 254 29 November 1991

Plasma Amino Acid Concentrations In Premature Infants: Effect Of Sampling Site (Michael R. Jones; Jeffrey M. Cheek; Junko Tamaki; John Edmond; and Paul YK Wu) The American Society for Clinical Nutrition 1989; 50: 1389-94

Phenylalanine Metabolites, Attention Span And Hyperactivity (K Michaels, RD, PhD; and R Matalon, MD, PhD) The American Journal of Clinical Nutrition 42: August 1985, pp 361-365

Immunocreative Beta-Endorphin Increases After An Aspartame Chocolate Drink In Healthy Human Subjects (J. C. Melchlor, D. Rigaud, N. Colas-Linhart, A. Petiet A Girard and M. Apfelbaum) February 21, 1991 Psychiatry and Behavior, Volume 50 pp941-944 Pergam Press

Friendly Fire In Medicine: Hormones, Homografts, And Creutzfeldt-Jakob Disease (Paul Brown, Michael A. Preece, Robert G. Will) The Lancett Vol 340: July 4, 1992

Postponement Of Satiety By Blockade Of Brain Cholecystokinin (CCK-B) Receptors (C.T. Dourish; W. Rycroft; S.D. Iversen) Science Vol. 245 29 September 1989

Effect Of Aluminum Ingestion On Aspartate Racemization In The Protein Of Rat Brain (Anderson, K.K., Perez, G.L., Fisher, G.H., Man, E.H.) Neuroscience Research Communications 1990; 6:45-50

Methanol Production From The Degradation Of Pectin By Human Colonic Bacteria (Ray J. Siragusa, MD; James J Cerda, MD: MM Baig, PhD; CW Burgin and FL Robbins, BS) American Journal for Clinical Nutrition 1988: 47" 848-51

Meta-Analyses Of Randomized Controlled Trials (Henry S. Sacks, PhD, MD; Jayne Berrier, MA; Dinah Reitman, MPS, VA; Ancona-Berk, PhD, and Thomas C. Chalmers, MD) The New England Journal of Medicine February 19, 1987 450-466

Peptide Synthesis Catalyzed By An Antibody Containing A Binding Site For Variable Amino Acids (Ralph Hirschmann, Amos B. Smith III, Carol M. Taylor, Patricia A. Benkovic, Scott D. Taylor, Kraig M. Yager, Paul A. Sprengeler, Stephen J. Benkovic) SCIENCE VOL. 265 8 July 1994

Structural Basis Of Amino Acid A Helix Propensity (Michael Biaber, Xue-jun Zhang, Brian W. Mathews) Science VOL. 260 11 JUNE 1993

Feedback Regulation Mechanisms For The Control Of GTP Cyclohydrolase I Activity (Toshie Harada, Hiroyuki Kagamiyama, Kazuyuki Hatakeyama) SCIENCE VOL. 260 4 June 1993

Nonnutritive Sweetener Consumption In Humans: Effects On Appetite And Food Intake And Their Putative Mechanisms Richard D. Mattes and Barry M Popkin Am J Clin Nutr 2009;89:1-14.

Formaldehyde, Aspartame, And Migraines: A Possible Connection Sharon E. Jacob and Sarah Stechschulte, Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL

Measurement Of Molecular Interaction Of Aspartame And Its Metabolites with DNA, George A. Karikas, Kleoptra H. Schulpis, George Reclos, and George Kokotos, Clinical Biochemistry , Volume 31, July 1998

Methanol: A Chemical Trojan Horse As The Root Of The Inscrutable U, Woodrow C. Monte, Medical Hypotheses 74(2010) 493-496

Aspartame And Headache
H.J. Roberts, MD
August 1995 NEUROLOGY 45 1631

Feedback Regulation Mechanisms For The Control Of TP Cyclohydrolase I Activity, Toshie Harada, Hiroyki Kagamiyama, Kazuyuki Hatakeyama, SCIENCE VOL.260 4 JUNE 1993

Direct And Indirect Cellular Effects Of Aspartame On The Brain, P Humphries, E Pretorius and H Naude, European Journal of Clinical Nutrition (2008) 62, 451-462

Sweetener Intakes
Fd Chem. Toxic. Vol. 29, No. 1, pp. 71-72, 1991

Increasing Brain Tumor Rates: Is There A Link To Aspartame?, John W. Olney, MD, Nuri B. Farber, Edward Spitznagel, and Lee N. Robins, Journal of Neuropathology and Experimental Neurology, Vol. 55, No. 11 November 1996 pp. 1115-1123

Artificial Sweeteners To Stay, The Jakarta Post-The Journal of Indonesia Today, National News-January 17, 2007

Nutritional And Toxicological Aspects Of Food Processing, Edited by R. Walker (University of Surrey, UK) and E. Quattrucci (Istituto Nazionale della Nutrizione, Rome), Proceedings of an International Symposium held at the Istituto Superiore di Sanita Rome, Italy 14-16 April 1987

Phenylalanine And Tyrosine Kinetics For Different Patterns And Indispensable Amino Acid Intakes In Adult Humans, J Sergio Marchini, Joaquin Cortiella, Takeyuki Hiramatsu, Leticia Castillo, Thomas E Chapman, and Vernon R Young, Am J Clin Nutr 1994;60:79-86

Structural Basis Of Amino Acid A Helix Propensity. Michael Blaber, Xue-jun Zhng, Brian W. Mathews, SCIENCE VOL. 260 11 JUNE 1993

Artificial Sweeteners Speed Alcohol Into Blood, Martha Kerr, Reuters Yahoo News Tue May 23, 2006

Regulation Of The Food Additive Aspartame: Food And Drug Administration Department Of Health, Education, And Welfare: Report Of The Comptroller General Of The United States, Author- United States, General Accounting Office, Publisher Info: [Washington]: U.S. General Accounting Office, 1976, SuDoc Number: GA 1. 13:MWD-76-111, OCLC Number: gp 76002488 (OcoLC) 2220253, System Number: 000002488

The Effect Of Aspartame On Rat Brain Xenobiotic-Metabolizing Enzymes Extracted from: http://www.ingentaconnect.com/content/sage/jet/2006/00000025/00000008/art00003

The Federal Regulation Of Food Labeling - Promoting Foods To Prevent Disease, David A. Kessler, M.D., J.D, From the Jack D. Weiler Hospital of the Albert Einstein College of Medicine, Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461

Query 1334 Aspartame, Project Number 5 R01 MH37320-06, Sucrose And Amphetamine In Normal And Hyperactive Children, Conners, C Keith, 111 Michigan Ave N W, Washington, D C 20010

Joint Pain Associated With Aspartame Use, H.J. Roberts, M.D., Townsend Letter for Doctors May 1991

New Perspectives Concerning Alzheimer's Disease, H.J. Roberts, M.D., 1989 Palm Beach County Medical Society. Published in On Call 1989: August: 14-16.

Memory Loss And Aspartame, Jody W. Zylke, MD, Editor, Questions and Answers, Journal of the American Medical Association, 515 N. State Street, Chicago, IL 60610

"yrosine - And Phenylalanine-Restricted Formula Diet Augments Immunocompetence In Healthy Humans, Jean R. Norris, Gary G Meadows, Linda K Massey, Jean R Starkey, Diane M Sylvester, and S-y Liu, Am J Clin Nutr 1990; 51:188-96

Excitatory Amino Acids As A Final Common Pathway For Neurologic Disorders, Stuart A. Lipton, M.D., Ph D., and Paul A. Rosenberg, M.D., Ph D, Mechanisms of Disease - Lipton and Rosenberg, Vol. 330 No. 9

Query 1334 Aspartame, Project Number 5 R37 AG00443-15, Gustatory And Olfactory Quality Changes With Age (Human), Schiffman, Susan S, Duke University, Dept. Of Psychology, Durham, NC 27706

Aspartame And Brain Cancer, Dr. H.J. Roberts, The Lancet Vol 349 * February 1, 1997

Reactions Attributed To Aspartame-Containing Products: 551 Cases, Hyman J. Roberts, M.D., Journal of Applied Nutrition, Volume 40, Number 2, 1998

Are Your Diet Sodas Killing You? Results From My Aspartame Experiment, Victoria Inness-Brown, http://www.Mercola.com

Aspartame Adminisered In Feed, Beginning Prenatally Through Life Span, Induces Cancers Of The Liver And Lung In Male Swiss Mice, Morando Soffritti, MD, Fiorella Belpoggi, DBS, Marco Manservigi, DBS, Eva Tibaldi, DBS, Michelina Lauriola, PhD, Laura Falcioni, DVM, and Luciano Bua, MD, American Journal of Industrial Medicine

Adverse Reactions To Aspartame: Double-Blind Challenge In Patients From A Vulnerable Poplulation, Ralph G. Walton, Robert Hudak, and Ruth J. Green-Waite, BIOL PSYCHIATRY 1993: 34: 13-17

Does Aspartame Cause Pre-Term Babies? Some EU Politicos Think So, Melanie Warner - May 20, 2011

The Effect Of Aspartame Administration On Oncogene And Suppressor Gene Expresstions, Katalin Gombos, Timea Varjas, Zsuzsanna Orsos, Eva Polyak, Judit Peredi, Zsuzsanna Varga, Ghodratollah Nowrasteh, Antal Tettinger, Gyula Mucsi, and Istvan Ember

Direct And Indirect Cellular Effects Of Aspartame On The Brain, P. Humphries, E. Pretorius andH. Naude, European Journal of Clinical Nutrition (2008) 62, 451-462

ABSTRACT, Norway Study, Aspartame Destroys Brain, Elisabeth Hetle og Arnstein Eltervaag, Hovedonngave 2001

Adverse Effects Of Aspartame, Prepared by Jacqueline van de Kamp, M.L.S., Specialized Services Division, January 1986 through December 1990, 167 Citations, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health